Staff in the working group of Prof. Kragl
Head of the Research Group
Head of the Research Group
- 1981 - 1987 Study of chemistry at University of Bonn
- 1987 Diploma, chemistry at University of Bonn and Forschungszentrum Jülich GmbH within the research group of Prof. Dr. Wandrey; title: „chemical reaction engineering of an enzyme-catalyzed cyanohydrin synthesis“
- 1988 - 1992 PhD-student, chemistry at University of Bonn and Forschungszentrum Jülich GmbH within the research group of Prof. Dr. Wandrey; title: „reaction engineering of biocatalytic prozesses, continous enzymatic synthesis of N-acetyl neuraminic acid"
- April - Sept. 1992 Guest scientist at Ciba Geigy Limited, International Research Laboratories, Takarazuka, Japan
- January 1998 Habilitation (post-doctoral lecturing qualification) at University of Bonn (experimental work at Forschungszentrum Jülich GmbH);
Title: „Reaction engineering of asymmetric syntheses with homogeneous and biocatalysts"
- April 1989 - November 1998 group leader 'biocatalysis' at the institute for biotechnology 2 within the Forschungszentrum Jülich GmbH (reseach center Jülich)
- July 1992 promotion to scientifc assistent (C1) at University of Bonn
- May 1998 promotion to senior scientific assistent (C2) at University of Bonn
- May 1998 granting of "authorisation to teach" (Privatdozent)
- July 1998 acception of an appointment from the University of Rostock - (bio)chemical reaction engineering (offical appointment: December 1998)
- January 2003 appointment from the TU Munich, rejected
- since July 2003 installation of the research group 'functionalisation of biogenic raw materials' at Leibniz-Institute for Catalysis, Rostock
- February 2007 - April 2007 visiting professor at National University of Singapore, Department of Chemistry, Singapore
- October 2007 - October2015 dean of the Faculty of Interdisciplinary Research, University of Rostock
- since October 2015 vice-rector of research and research education, University of Rostock
Staff at Institute of Chemistry at Rostock University
- since 2014 Head of the electrochemistry group at Rostock University (Department of Chemistry, Industrial Chemistry Division); Liebig-fellowship since 2015
- 2012-2014 Postdoctoral fellow in the group of Prof. R. D. Little at University of California Santa Barbara (USA); Feodor-Lynen-fellowship (2012-2014)
- 2009-2012: PhD student in the group of Prof. S. R. Waldvogel (Mainz University); Title of thesis: “Highly Fluorinated Materials for Energy Storage Electrolytes - From Synthesis to Application”
- 2007/2008: Visiting Scientist at Alicante University (Spain) with Prof. J. M. Feliu
- 2003-2008: Studies in chemistry at Bonn University
- Organic electrosynthesis
- Electroanalytical chemistry
- Organic chemistry
- Electrochemical energy storage
- since 2018 Scientific Researcher „Sustainable Chemistry“ in the group of Prof. Dr. Udo Kragl at the University of Rostock / Interdsiziplinäry Faculty
- since 2016 Project coordinator RoHan DAAD SDG Graduate School “Catalysis as key towards Sustainable Ressource Management“ (www.rohan-sdg.com)
- 2010-2017 Scientific Researcher „In situ Spektroscopy/Water splitting/Photocatalysis“ in the group of Prof. Angelika Brückner at the Leibniz-Institute for Catalysis
- 2009 Postdoc in the group of Prof. Karl Anker Jørgensen at the Center of Catalysis, University of Aarhus, Danmark
- 2006-2009 PhD student in the group of Prof. Matthias Beller at the Leibniz-Institute for Catalysis
- 2005 Diplom/Master student in the group of Prof. Siegfried Blechert, Technical University Berlin
- 2002-2003 Student at the University of Strathclyde, Glasgow, Scotland
- 2000-2005 Undergraduate Studies at the Technical University Berlin
- Sustainable Chemistry
- Applied Photocatalysis
- Photoactive membranes
- Photoactive Supported Ionic Liquids
- Application in developing countries
Researcher ID: E-4434-2013
38. Beweries, T., Reiß, F., Reiß, M., Spannenberg, A., Jiao, H., Hollmann, D., Arndt, P., Rosenthal, U., "Titanocene silylpropyne complexes - promising intermediates en route to a four-membered 1-metallacyclobuta-2,3-diene?" Chem. Eur. J. (2017) 23 (57), 14158
39. Helmdach, K., Ludwig, S., Villinger, A., Hollmann, D., Kosters, J., Seidel, W. W., "Synthesis and activation potential of an open shell diphosphine" Chem. Commun. (2017) 53 (43), 5894
40.Hollmann, D., Rockstroh, N., Grabow, K., Bentrup, U., Rabeah, J., Polyakov, M., Surkus, A.-E., Schuhmann, W., Hoch, S., Brückner, A., "From the Precursor to the Active State: Monitoring Metamorphosis of Electrocatalysts During Water Oxidation by In Situ Spectroscopy" ChemElectroChem (2017) 4 (8), 2117
41. Indra, A., Acharjya, A., Menezes, P. W., Merschjann, C., Hollmann, D., Schwarze, M., Aktas, M., Friedrich, A., Lochbrunner, S., Thomas, A., Driess, M., "Boosting Visible-Light-Driven Photocatalytic Hydrogen Evolution with an Integrated Nickel Phosphide–Carbon Nitride System" Angew. Chem. Int. Ed. (2017) 56 (6), 1653
42. Indra, A., Acharjya, A., Menezes, P. W., Merschjann, C., Hollmann, D., Schwarze, M., Aktas, M., Friedrich, A., Lochbrunner, S., Thomas, A., Driess, M., "Boosting Visible-Light-Driven Photocatalytic Hydrogen Evolution with an Integrated Nickel Phosphide–Carbon Nitride System" Angew. Chem. (2017) 129 (6), 1675
43. Mejía, E., Brisar, R., Hollmann, D., "Pyrazine Radical Cations as Catalyst for the Aerobic Oxidation of Amines" European Journal of Organic Chemistry (2017) (36), 5391
44. Reiß, F., Altenburger, K., Hollmann, D., Spannenberg, A., Jiao, H., Arndt, P., Rosenthal, U., Beweries, T., "Redox-Disproportionation of a Decamethyltitanocene(III) Isonitrile Alkynyl Complex" Chem. Eur. J. (2017) 23 (33), 7891
45. Yang, F., Xia, W., Maljusch, A., Masa, J., Hollmann, D., Sinev, I., Cuenya, B. R., Schuhmann, W., Muhler, M., "NH3 Post-Treatment Induces High Activity of Co-Based Electrocatalysts Supported on Carbon Nanotubes for the Oxygen Evolution Reaction" ChemElectroChem (2017) 4 (8), 2091
- Since 2019 postdoctoral fellow in the working group of Prof. Dr. Udo Kragl, University of Rostock
- 2016-2018 PhD student in the working group of Prof. Dr. Peter Langer, University of Rostock, topic: "Functionalization of anticoagulant and estrogenic active substances and natural substances".
- 2014-2015 Research associate at the Leibniz Institute for Catalysis at the University of Rostock, topic: "Development of new organocatalysed processes based on phosphane-containing catalysts".
- 2009-2014 Bachelor and Master Degree in Chemistry at the University of Rostock, Germany
- Organic Synthesis
- Modification of active substances
Bioavailability of natural active substances
Coordinated by University Medicine Greifswald with partners from the University of Greifswald, the Albrecht-Kossel-Institute and the Institute of Chemistry at the University of Rostock, and the Leibniz Institute for Catalysis in Rostock and financial supported from the EU, as part of the state of Mecklenburg-Vorpommern’s Research Excellence Programme we work in the projekt Protein Misfolding, ER-Stress and Protein Degradation(PePPP). Our goal is to develop a systematic pipeline for individualised therapy in hereditary disorders of the pancreas and liver. Besides the extraction and characterisation of therapeutic substances, which either inhibit ER-Stress or repair the cell’s defective degradation of false proteins we also want to influence their bioavailability by derivatisation of functional groups of lignans or flavonids.
7. S. Jopp, P. Ehlers, E. Frank, E. Mernyák, G. Schneider, J. Wölfling, A. Villinger, P. Langer, "Site-Selective Synthesis of 3,17-Diaryl-1,3,5,16-estratetraenes" Synlett 2019, 30, 600–604.
6. S. Jopp, T. Wallaschkowski, P. Ehlers, E. Frank, G. Schneider, J. Wölfling, E. Mernyák, A. Villinger, P. Langer, Chemoselective Suzuki-Miyaura reactions of 4-bromo-3-O-triflylestrone. Synthesis and atropisomerism of arylated estrones" Tetrahedron 2018, 74, 2825–2836.
5. S. Jopp, M. Liesegang, P. Ehlers, E. Frank, G. Schneider, J. Wölfling, P. Langer, "Synthesis of novel 16-E-(arylidene)-3-methoxy-alpha-estrones via a palladium catalysed Suzuki-Miyaura reaction" Tetrahedron Lett. 2018, 59, 26–27.
4. S. Jopp, M. Liesegang, P. Ehlers, E. Frank, G. Schneider, J. Wölfling, A. Villinger, P. Langer, "Palladium-Catalysed Sonogashira Reactions of 16-(Hydroxymethylidene)- 3-methoxy-α-estrone" Synlett 2017, 28, 2647–2649.
3. S. Riebe, S. Jopp, P. Ehlers, E. Frank, G. Schneider, J. Wölfling, A. Villinger, P. Langer, "Synthesis of 16-E-([aryl]idene)-3-methoxy-estrones by a palladium catalysed Mizoroki-Heck reaction" Tetrahedron Lett. 2017, 58, 2801–2803.
2. M.-L. Schirmer, S. Jopp, J. Holz, A. Spannenberg, T. Werner, "Organocatalyzed Reduction of Tertiary Phosphine Oxides" Adv. Synth. Catal. 2016, 358, 26–29.
1. P. Ehlers, A. Petrosyan, J. Baumgard, S. Jopp, N. Steinfeld, T. V. Ghochikyan, A. S. Saghyan, C. Fischer, P. Langer, "Synthesis of 2,5-Diarylpyrroles by Ligand-Free Palladium- Catalyzed CH Activation of Pyrroles in Ionic Liquids" ChemCatChem 2013, 5, 2504–2511.
- 2005-2008 PhD-student within the research group of Prof. Dr. Udo Kragl at the University of Rostock, Germany
- 2007 Guest scientist at Institute of Chemical Process Fundamentals ASCR, v.v.i. in Prague, Czech Republic
- 2008 PhD-thesis: “Medium-engineering for enzymatic reactions, different examples of hydroxynitrile lyases and alcohol dehydrogenases“
- 2008-2011 Postdoc at Max-Planck-Institute for Dynamics for complex technical Systems, Germany within the research group of Prof. Dr. Andreas Seidel-Morgenstern
- 2010 Guest scientist at Astrazeneca AB in Södertälje, Sweden
- 2012 Postdoc at University of Minnesota in Saint Paul, USA within the research group of Prof. Dr. Romas J. Kazlauskas
- seit 2013 Group leader 'biocatalysis' at University of Rostock, Germany
- enantioselective biocatalysis
- novel (integrated) reaction concepts
- cascade reactions
- crystallisation of enantiomers
- 2002-2008 Studies in Chemistry at Rostock University
- 2008 Diploma thesis within the growth core ‚BioOK’
Title: "Comparative analysis of free amino acids in transgenic and conventional plants using LC/MS“
- 2008-2013 PhD student in the research group of Prof. Dr. Udo Kragl at Rostock University
Title: "Secondary plant ingredients for cancer prevention and therapy“
- since 2013 research scientist in the research group of Prof. Dr. Udo Kragl at Rostock University
- Analytical Chemistry
- Structural analysis of natural products
Bioavailability of natural active substances
(9) Lukas J., Pospech J., Oppermann C., Hund C., Iwanov K., Pantoom S., Petters J., Frech M., Seemann S., Thiel F., Modenbach J.M., Bolsmann R., de Freitas Chama L., Kraatz F., El-Hage F., Gronbach M., Klein A., Müller R., Salloch S., Weiss F.U., Simon P., Wagh P., Klemenz A., Krüger E., Mayerle J., Delcea M., Kragl U., Beller M., Rolfs A., Lerch M.M., Sendler M.: "Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas" (2019) submitted to Advances in the Medical Sciences
(8) Falfushynska H., Sokolov E.P., Haider F., Oppermann C., Kragl U., Ruth W., Stock M., Glufke S., Winkel E. J., Sokolova I.M.: Effects of a common pharmaceutical atorvastatin, on energy metabolism and detoxification mechanisms of a marine bivalve Mytilus Edulis." (2019) Aquatic Toxicology 208, p.47-61, https://doi.org/10.1016/j.aquatox.2018.12.022
(7) Oppermann, S., Oppermann, C., Böhm, M., Kühl, T., Imhof, D., Kragl, U.: "Quantification of amino acids and peptides in an ionic liquid based aqueous two-phase system by LC-MS analysis" (2018) AMB Express, 8:66
(6) Engel N., Müller P., Duske K., Oppermann C., Kraft K., Nebe B.: “Cytoskeletal remodeling of MCF-7 breast cancer cells under the treatment of the native root extract of Linum usitatissimum.” (2015) Advancement in Medicinal Plant Research; 3(3): 92-105
(5)Oppermann C., Engel N., Ruth W., Nebe B., Kragl U.: LC-MS analysis of extracts from beech and sea buckthorn to correlate the phytoestrogen content and anti-cancer activity. Journal of Chemical and Pharmaceutical Research, Vol. 7 (5), 175-185 (2015)
(4) Stapel J., Oppermann C., Richter D.U., Ruth W., Briese V.: Anti-carcinogenic effects of ethanolic extracts from root and shoot of Lupinus angustifolius on the breast carcinoma cell lines MCF-7 and BT20. Journal of Medicinal Plants Research, Vol. 9 (17), 561-568 (2015)
(3) Stapel J., Oppermann C., Richter D.U., Ruth W., Briese V.: Polyphenol compounds with anti-carcinogenic qualities: Effects of quercetin (flavonol), chrysin (flavon), kaempferol (flavanol), naringenin (flavanon) and hesperidin (flavanoid) on in vitro breast cancer. Journal of Medicinal Plants Research, Vol. 7 (29), 2187-2196 (2013)
(2) Falodun A., Engel N., Oppermann C., Iftikhar A., Villinger A., Kragl U., Nebe B., Langer P. : Isolation of Trimyethylammoniumyl-acetate monohydrate from Cola lepidota seeds: Antiproliferative Activity of Extracts and Fractions. Journal of Herbs, Spices & Medicinal Plants 19, 329–339 (2013)
(1) Engel N., Oppermann C., Falodun A., Kragl U.: Proliferative effects of traditional Nigerian medicinal plant extracts on human breast and bone cancer cell lines. Journal of Ethnoparmacology 137, 1003-1010 (2011)
The aim of the work is the synthesis of hydrogels based on polymerizable ionic liquids for research into novel drug delivery systems. The focus is on the controlled and stimulus-responsive release of active ingredients.
Office: LL&M 247
Lab: LL&M 122
Extraction and characterization of new natural active substances
As part of the “Exzellenzinitative Mecklenburg-Vorpommern” 11 working groups from Rostock and Greifswald collaborate in the so called PePPP project. The aim of this cooperation is to establish a systematic pipeline for the individualized therapy of hereditary liver and pancreas diseases.
As a Ph. D. student I will extract and characterize active substances from different natural sources, which will hopefully show a positive reaction against the causes of the hereditary diseases.
Crystallisation in transaminase-catalysed reactions
The aim of the work is the preparation of chiral amines by transaminase-catalysed reactions. The unfavorable equilibrium and complex downstream processing should be overcome by in situ-product crystallisation (ISPC).
Biocatalytic Carboxylation Reactions
The regioselective enzymatic carboxylation of aromatic compounds is investigated. To avoid the unfavourable equilibrium, new methods will be applied among others by extracting the carboxylated product.
The study on the separation process to recover carbohydrate derivatives from catalytic conversion of rice straw. These carbohydrates are considered as a sustainable feedstock to substitute for fossil resources in production of fuels and chemicals. Although there are multiple methods for rice straw conversion, the use of catalysts has more advantages to achieve carbohydrate derivatives with high selectivity. And mechanochemistry that carried out in the planetary ball mill seems to be a very promising and easy approach.
Office: LL&M 247
Lab: LL&M 122
The increased consumption of fossil fuels leads to their progressive scarcity in connection with a continuous emission of carbon dioxide as climate-damaging greenhouse gas. A conversion of carbon dioxide into reactive C1-building blocks allows a return to the usable energy cycle or the useage as a C1 building block in synthesis. One possability to archive this is the electrochemical reduction, which offers the advantage of replacing the necessary reducing agent with electrical current. Problems such as high overpotantial or low product-selectivity during the direct reduction can be avoided by the use of electrocatalysts. My research focuses on the mechanistic investigation of the electrocatalytic reduction of carbon dioxide to carbon monoxide by molecularly defined catalysts. The improved understanding of the reaction is intended to optimize the reaction conditions and the molecular structure of the catalysts.
Membranes and Ionic Liquids
The term Ionic Liquid (IL) describes salts whose melting point are lower than 100 °C. They possess several interesting properties such as thermal stability, poor volatility, ionic and electric conductivity. Since their discovery in 1914 and naming in the 1940s many of these “designer solvents” were published. The aim of my work is to polymerize ionic liquids. Those obtained Polymerized Ionic Liquids (PILs) combine the advantages of ILs and tight polymer backbones. Main focus will be the casting of PILs to membranes and their application in regard to extraction or dialysis
Office: LL&M 247
Lab: LL&M 122
Staff at Leibniz-Institute of Catalysis
- 1999-2004: Bachelor in Chemistry at the National University of Colombia, Bogota, Colombia. Undergraduate thesis: "Synthesis of a Novel Organometallic Compound With Possible Application in Stereoselective Catalysis" Awarded: Meritorious Mention (National University of Colombia, 2005), National Contest of Best Undergraduate Thesis, 3rd Place in the area of Natural Sciences (National University of Colombia, 2006).
- 2005-2007: Master of Sciences (Chemistry) at the National University of Colombia, Bogota, Colombia, in the group of Prof. Ricardo Fierro. Master thesis entitled: “New Organometallic Titanium Compounds with Chalcogen-Ether Type Ligands: Synthesis, Characterization and Use in Styrene Polymerization”.
- 2008-2011: Doctor of Sciences at the Swiss Federal Institute of Technology (ETH Zurich), Zurich, Switzerland, in the group of Prof. Antonio Togni. Doctoral dissertation: "New Rhenium-Catalyzed Reactions: From Asymmetric Hydrogenation to Trifluoromethylation”
- 2012: Postdoctoral research associate at Leibniz Institut für Katalyse e V. (LIKAT) in the group of Prof. Matthias Beller working in the development and applications of new organometallic catalysts for photocatalytic water reduction.
- 2013-2014: Associate research scientist at Leibniz Institut für Katalyse e V. (LIKAT) in the group of Prof. Udo Kragl working in the development of polymerization catalysts, monomers and processes on a joint project with Henkel AG.
- 2015-2016: Project leader at Leibniz Institut für Katalyse e V. (LIKAT) in the Department of Polymer Chemistry and Catalysis (Prof. Udo Kragl) Since
- 2017: Junior Research Group leader at Leibniz Institut für Katalyse e V. (LIKAT), group “Polymer Chemistry and Catalysis” (Prof. Udo Krag)
- Homogeneous catalysis
- Inorganic (Coordination) and Organometallic chemistry
- Organic, Inorganic and Organometallic synthesis
- Ligand design
- Polymer chemistry
Junior Research Group Leader for Polymer Chemistry and Catalysis
Former Staff Members
Christine Arndt · Jenny Bandomir · Jens Baumgard · Michael Belter · Robert Bratsch · Rok Brisar · Jessica Bronkal · Timo Bröse · Karin Buchholz · Juliane Buhrtz · Juliana Buß · Saskia Dahse · Daniela Degenring · Thomas Deierling · Johannes Diebler · Susanne Dreyer · Petra Duncker · Julia Duwensee · Torsten Dwars · Marrit Eckstein · Anett Endrejat · Claudia Engelmann · Friedrich Erben · Thomas Fahrenwaldt · Christel Freitag · Ria Fritz · Sven Gebhardt · Swarup Ghosh · Kathleen Grabow · Julia Großeheilmann · Anja Gummesson · Daniela Hameister · Jörn Hameister · Steve Hillbrandt · Janine Hinze · Diana Höffer · Donald Höpfner · Annett Horn · Sabine Illner · Pavel Izak · Ulrike Jost · Nicole Kaftzik · Anja Kammer · Sandra Klembt · Anne Koch · Stefanie Kohse · Patrick Kollmorgen · Marcus Kordian · Susanne Koth · Lisa Krey · Jan Kröckel · Sina Kummer · Shefali Kumar · Katharina Kunna · Fanny Langschwager · Henrik Lund · Ines Masuck · Annett Mell · Katja Neubauer · Lorenz Neubert · Julita Opalach · Sebastian Oppermann · Anne-Kathrin Paul · Ayla Päpcke · Jan Christoph Peinemann · Ramona Pilz · Regina Plagemann · Henry Postleb · Sebastian Przymusinski · Juliane Ratzka · Melanie Reiß · Daniel Riemer · Anne Roock · Wolfgang Ruth · Martin Ruhmann · Benjamin Schille · Christin Schmidt · Sonja Schöfer · Enno Schönborn · André Schulz · Paul Schulz · Christine Schütz · Florian Stein · Christoph Stelt · Dirk Strübing · Marco Tänzler · Miriam Tomasch · Sebastian Trapp · Diana Uhrich · Jana Unger · Juliane Vlach · Christian von der Ehe · Christian Vogl · Dengxu Wang · Stefanie Wapenhensch · Peggy Wefers · Anne Willert · Marleen Winterberg · Thomas Witzke · Marta Woznicka · Xuee Wu · Beatrice Zechow · Vera Zimmermann