Publikationen von Prof. Dr. Udo Kragl



(172) Falfushynska, H.; Sokolov, E. P.; Haider, F.; Oppermann, C.; Kragl, U.; Ruth, W.; Stock, M.; Glufke, S.; Winkel, E. J.; Sokolova, I. M.
Effects of a common pharmaceutical, atorvastatin, on energy metabolism and detoxification mechanisms of a marine bivalve Mytilus edulis.
Aquatic Toxicology 208, 47-61 (2019)



(171)  Meyer, L.-E.; Plasch, K.; Kragl, U.; von Langermann, J.
Adsorbent-Based Downstream-Processing of the Decarboxylase-Based Synthesis of 2,6-Dihydroxy-4-methylbenzoic Acid.
Organic Process Research and Development 22, 963-970 (2018)

(170) Meyer, L.-E.; von Langermann, J.; Kragl, U.
Recent developments in biocatalysis in multiphasic ionic liquid reaction systems.
Biophysical Reviews 10, 901-910 (2018)

(169) Ghosh, S.; Pahovnik, D.; Kragl, U.; Mejía, E.
Isospecific Copolymerization of Cyclohexene Oxide and Carbon Dioxide Catalyzed by Dialkylmagnesium Compounds.
Macromolecules 51, 846-852 (2018)

(168) Engelmann, C. and Kragl, U.
Spray congealing as innovative technique for enzyme encapsulation.
Journal of Chemical Technology and Biotechnology 93, 191-197 (2018)

(167) Claus, J.; Sommer, F.O.; Kragl, U.
Ionic liquids in biotechnology and beyond.
Solid State Ionics 314, 119-128 (2018)



(166) Brietzke, A.; Von Der Ehe, C.; Illner, S.; Matschegewski, C.; Grabow, N.; Kragl, U.
Promising biocompatible hydrogels of crosslinked polyelectrolytes for biomedical applications.
Current Directions in Biomedical Engineering 3, 695-698 (2017)

(165) Steinbauer, J.; Longwitz, L.; Frank, M.; Epping, J.; Kragl, U.; Werner, T.
Immobilized bifunctional phosphonium salts as recyclable organocatalysts in the cycloaddition of CO2 and epoxides.
Green Chemistry 19, 4435-4445 (2017)

(164) Kottmann, A.; Mejia, E.; Hemery, T.; Klein, J. and Kragl, U.
Recent Developments on the Preparation of Silicones with Antimicrobial Properties.
Chemistry - An Asian Journal 12, 1168-1179 (2017)

(163) Großeheilmann, J. and Kragl, U.
Simple and Effective Catalyst Separation by Novel CO2-induced Switchable Organocatalysts.
ChemSusChem 10, 2685-2691 (2017)

(162) Jost, U.; Andreeßen, B.; Michalik, D.; Steinbüchel, A.; Kragl, U.
Downstream processing of serinol from a glycerol-based fermentation broth and transfer to other amine containing molecules.
Engineering in Life Science 17, 479-488 (2017)

(161) Reimer, A.; Wedde, S.; Staudt, S.; Schmidt, S.; Höffer, D.; Hummel, W.; Kragl, U.; Bornscheuer, U. T.; Gröger, H.
Process Development through Solvent Engineering in the Biocatalytic Synthesis of the Heterocyclic Bulk Chemical ε‐Caprolactone
Journal of Heterocyclic Chemistry 54, 391-396 (2017)

(160)  Kummer, S.; Klembt, S.; Ruth, W.; Kragl, U.
Transfer of ionic liquids across the water/1, 2-dichloroethane interface.
Journal of Molecular Liquids 226, 85-89 (2017)



(159) Beck, M.; Neise, C.; Ahrenberg, M.; Schick, C.; Kragl, U.; Kessler, O.
Heat transfer mechanisms analysed by high speed video recording of metal quenching in ionic liquids and water.
International Journal of Microstructure and Materials Properties 11 (5), 359-372 (2016)

(158) Ahrenberg, M.; Beck, M.; Neise, C.; Keßler, O.; Kragl, U.; Verevkin, S. P.; Schick, C.
Vapor pressure of ionic liquids at low temperatures from AC-chip-calorimetry
Physical Chemistry Chemical Physics 18 (31), 21381-21390 (2016)

(157) Deng, H.; Dick, J. E.; Kummer, S.; Kragl, U.; Strauss, S. H.; Bard, A. J.
Probing Ion Transfer across Liquid–Liquid Interfaces by Monitoring Collisions of Single Femtoliter Oil Droplets on Ultramicroelectrodes
Analytical Chemistry 88 (15), 7754-7761 (2016)

(156) Kummer, S.; Ruth, W.; Kragl, U.
Electrochemical Initiated C‐N Coupling of 3‐Methylcatechol and n‐Hexylamine in a Flow Cell Monitored with ESI‐MS
Electroanalysis 28, 1992 (2016)

(155) Kummer, S.; Ruth, W.; Kragl, U.
Oxidation of Flavonols in an Electrochemical Flow Cell Coupled Online with ESI‐MS
Electroanalysis 28, 990-997 (2016)

(154) Ludwig, R.; Wagner, J.; Beller, M.; Brückner, A.; Kragl, U.; Kühn, O.
Editorial of the PCCP themed issue on “Basic Mechanisms in Energy Conversion”
Physical Chemistry Chemical Physics 18 (16), 10680-10681 (2016)

(153) Großeheilmann, J.; Vanderveen, J. R.; Jessop, P. G.; Kragl, U.
Switchable‐Hydrophilicity Solvents for Product Isolation and Catalyst Recycling in Organocatalysis
ChemSusChem 9 (7), 696-702 (2016)

(152) Graiff, A.; Ruth, W.; Kragl, U.; Karsten, U.
Chemical characterization and quantification of the brown algal storage compound laminarin—A new methodological approach
Journal of Applied Phycology 28 (1), 533-543 (2016)

(151) Neise, C.; Rautenberg, C.; Bentrup, U.; Beck, M.; Ahrenberg, M.; Schick, C.; Keßler, O.; Kragl, U.
Stability studies of ionic liquid [EMIm][NTf 2] under short-term thermal exposure
RSC Advances 6 (54), 48462-48468 (2016)

(150) Großeheilmann, J.; Fahrenwaldt, T.; Kragl U.
Organic Solvent Nanofiltration-Supported Purification of Organocatalysts
ChemCatChem 8, 322-325 (2016)



(149) Großeheilmann, J.; Bandomir, J.; Kragl U.
Preparation of Poly(ionic liquid)s-supported Recyclable Organocatalysts
for the Asymmetric Nitroaldol (HENRY) Reaction
Chemistry - A European Journal 21 (25), 18957-18960 (2015)

(148) Seidensticker, T.; Furst, M. R.; Frauenlob, R.; Vondran, J.; Paetzold, E.; Kragl, U.; Vorholt, A. J.
Palladium‐Catalyzed Aminocarbonylation of Aliphatic Alkenes with N, N‐Dimethylformamide as an In Situ Source of CO
ChemCatChem 7 (24), 4085-4090 (2015)

(147) Süss, P.; Borchert, S.; Hinze, J.; Illner, S.; von Langermann, J.; Kragl, U.; Bornscheuer, U. T.; Wardenga, R.
Chemoenzymatic Sequential Multistep One-Pot Reaction for the Synthesis of (1 S, 2 R)-1-(Methoxycarbonyl) cyclohex-4-ene-2-carboxylic Acid with Recombinant Pig Liver Esterase
Organic Process Research & Development 19 (12), 2034-2038 (2015)

(146) Großeheilmann, J.; Büttner, H.; Kohrt, C.; Kragl, U.; Werner, T.
Recycling of Phosphorus-based Organocatalysts by Organic Solvent Nanofiltration
ACS Sustainable Chemistry & Engineering 3 (11), 2817-2822 (2015)

(145) Engelmann, C.; Illner, S.; Kragl, U.
Laccase initiated C-C couplings: Various techniques for reaction monitoring
Process Biochemistry 50, 1591-1599 (2015)

(144) Beck, M.; Schmidt, C.; Ahrenberg, M.; Schick, C.; Kragl, U.; Kessler, O.
Ionic Liquids as New Quenching Media for Aluminium Alloys and Steels
Journal of Heat Treatment Materials 70 (2), 73-80 (2015)

(143) Graiff, A.; Ruth, W.; Kragl, U.; Karsten, U.
Chemical characterization and quantification of the brown algal storage compound laminarin - A new methodological approach
Journal of Applied Phycology 28 (1), 533-543 (2015)

(142) Kaule, S.; Minrath, I.; Stein, F.; Kragl, U.; Schmidt, W.;Schmitz, K.-P.; Sternberg, K.; Petersen, S.
Correlating Coating Characteristics with the Performance of Drug-Coated Balloons - A comparative in vitro Investigation of own established Hydrogel- and Ionic Liquid-based Coating Matrices
PLoS ONE 10 (3): e0116080 (2015)

(141) Bandomir, J.; Kaule, S.; Schmitz, K.-P.; Sternberg, K.; Petersen, S.; Kragl, U.
Usage of different vessel models in a flow-through cell: in vitro study of a novel coated balloon catheter
RSC Advances 5, 11604-11610 (2015)



(140) Schmidt, C.; Beck, M.; Ahrenberg, M.; Schick, C.; Keßler, O.; Kragl, U.
Room temperature ionic liquids in a heat treatment process for metals
RSC Advances 4, 55077-55081 (2014)

(139) Kohse, S.; Neubauer, A.; Lochbrunner, S.; Kragl, U.
Improving the Time Resolution for Remote Control of Enzyme Activity by a Nanosecond Laser Induced pH-Jump
ChemCatChem 6, 3511-3517 (2014)

(138) Baumgard, J.; Pohl, M.-M.; Kragl, U.; Steinfeldt, N.
Preparation of tailor-made supported catalysts using asymmetric flow field fractionation and their application in hydrogenation
Nanotechnology Reviews 3, 87-98 (2014)

(137) Plagemann, R.; Langermann, J.; Kragl, U.
Microwave assisted covalent immobilization of enzymes on inorganic surfaces
Engineering in Life Sciences 14, 493-499 (2014)

(136) Hameister, D.; Illner, S.; Vogel, C.; Michalik, D.; Kragl, U.
Application and mechanism of carrier facilitated carbohydrate extraction from aqueous solution 
Separation and Purification Technology 132, 438-445 (2014)

(135) Süss, P.; Illner, S.; Langermann, J.; Borchert, S.; Bornscheuer, U. T.; Wardenga, R.; Kragl, U.
Scale-Up of a Recombinant Pig Liver Esterase-Catalyzed Desymmetrization of Dimethyl Cyclohex-4-ene-cis-1,2-dicarboxylate
Organic Process Research & Development 18, 897-903 (2014)

(134) Illner, S.; Hofmann, C.; Löb, P.; Kragl, U.
A Falling-Film Microreactor for Enzymatic Oxidation of Glucose
ChemCatChem 6, 1748-1754 (2014)

(133) Kummer, S.; Ruth, W.; Kühn, O.; Kragl, U.
Comparison of Electrochemical Oxidation of Flavonols and Claculated Proton Affinity and Electron Transfer Enthalpy in Water
Electroanalysis 26, 910-918 (2014)

(132) Diebler, J.; Langermann, J.; Mell, A.; Hein, M.; Langer, P.; Kragl, U.
Synthesis of Aliphatic and α-Halogenated Ketone Cyanohydrins with the Hydroxynitrile Lyase from Manihot esculenta
ChemCatChem 6, 987-991 (2014)

(131) Bandomir, J.; Schulz, A.; Taguchi, S.; Schmitt, L.; Ohno, H.; Sternberg, K.; Schmitz, K.-P.; Kragl, U.
Synthesis and Characterisation of Polymerized Ionic Liquids: Mechanical and Thermal Properties of a Novel Type of Hydrogels
Macromolecular Chemistry and Physics 215, 716-724 (2014)

(130) Illner, S.; Plagemann, R.; Saling, P.; Kragl, U.
Eco-efficiency analysis as a reaction-engineering tool - Case study of a laccase-initiated oxidative C-N coupling
Journal of Molecular Catalysis B: Enzymatic 102, 106-114 (2014)

(129) Engel, N.; Falodun, A.; Kuehn, J.; Kragl, U.; Langer, P.; Nebe, B.
Pro-apoptotic and anti-adhesive effects of four African plant extracts on the breast cancer cell line MCF-7
Bmc Complementary and Alternative Medicine 14, 334 (2014)
Journal of Molecular Catalysis B: Enzymatic 102, 106-114 (2014)

(128) Ahrenberg, M.; Brinckmann, M.; Schmelzer, J.; Beck, M.; Schmidt, C.; Keßler, O.; Kragl, U.; Verevkin, S.; Schick, C.
Volatility of ionic liquids at the nanoscale by means of ultrafast scanning calorimetry
Physical Chemistry Chemical Physics 16, 2971-2980 (2014)



(158) Falodun, A.; Engel-Lutz, N.; Oppermann, C.; Iftikar, A.; Villinger, A.; Kragl, U.; Nebe, B.; Langer, P.
Isolation of Trimethylammoniumyl-Acetate Monohydrate from Cola Lepidota Seeds: Antiproliferative Activity of Extracts and Fractions
Journal of Herbs, Spices & Medicinal Plants 19, 329-339 (2013)

(157) Fahrenwaldt, T.; Großeheilmann, J.; Erben, F.; Kragl, U.
Organic solvent nanofiltration as a tool for separation of quinine-based organocatalysts
Organic Research & Development 17, 1131-1136 (2013)

(156) Beck, M.; Schmidt, C.; Ahrenberg, M.; Schick, C.; Kragl, U.; Keßler, O.
The ideal quenching medium? Chracterisation of ionic liquids for heat treatment of metallic components
Journal for Heat Treatment of Materials 68, 213-223 (2013)

(155) Peterson, S.; Kaule, S.; Stein, F.; Minrath, I.; Schmitz, K.-P.; Kragl, U.; Sternberg, K.
Novel paclitaxel-coated angioplasty balloon catheter based on cetylpyridinium salicylate: Preparation, characterization and simulated use in an in vitro vessel model
Materials Science and Engineering C 33, 4244-4250 (2013)

(154) Kohse, S.; Neubauer, A.; Pazidis, A.; Lochbrunner, S.; Kragl, U.
Photoswitching of Enzyme Activity by Laser Induced pH-jump
Journal of the American Chemical Socity 135, 9407-9411 (2013)

(153) Vu, T. V.; Kosslick, H.; Schulz, A.; HArloff, J.; Paetzold, E.; Radnik, J.; Kragl, U.; Fulda, G., Janiak, C.; Tuyen, N. D.
Hydroformylation of Olefins of Rhodium Supported Metal-organic Framework Catalysts of Different Structure
Microporous and Mesoporous Materials 177, 135-142 (2013)

(152) Liese, A.; Kragl, U.
Einfluss der Reaktorkonfiguration auf die Enantioselektivität einer kinetischen Racematspaltung
Chemie-Ingenieur-Technik 85, 826-832 (2013)

(151) Falodun, A.; Engel-Lutz, N.; Kragl, U.; Nebe, B.; Langer, P.
Novel anticancer alkene lactone from Persea americana
Pharmaceutical Biology 51, 700-706 (2013)

(150) Baumgard, J.; Vogt, A. M.; Kragl, U.; Jähnisch, K.; Steinfeldt, N.
Application of micro structured devices for continuous synthesis of tailored platinum nanoparticles,
Chemical Engineering Journal 227, 137-144 (2013)



(149) Adryan, P.; Brandenburg, G.; Hameister, D.; Höffer, D.; Illner, S.; Kragl, U.; Moritz, H.-U.; Müller, C. M.; Pauer, W.; Räbiger, N.; Rößner, F.; Schlüter, M.; Shell, M.; Sleumer, K.
Mixing and Reactions in Microchannels - an Educational Approach using the Internet
Chemie-Ingenieur-Technik 84, 1505-1512 (2012)

(148) Van Vu, T.; Kosslick, H.; Schulz, A.; Harloff, J.; Paetzold, E.; Lund, H.; Kragl, U.; Schneider, M.; Fulda, G.
Influence of the textural properties of Rh/MOF-5 on the catalytic properties in the hydroformylation of olefins
Microporous and Mesoporous Materials 154, 100-106 (2012)

(147) Falodun, A.; Kragl, U.; Tengho Touem, S.-M.; Villinger, A.; Fahrendwaldt, T.; Langer, P.
A novel anticancer dipertenoid from Jatropha gossypifolia
Natural Product Communications 7, 151-152 (2012)

(146)  Köddermann, T.; Klembt, S.; Klasen, D.; Paschek, D.; Kragl, U.; Ludwig, R.
The Effect of Neutral Ion Aggregate Formation on the Electrical Conductivity of the Ionic Liquid 1-n-Ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide and its Mixtures with Chloroform: Experiments and MD Simulations
ChemPhysChem 13, 1748-1752 (2012)

(145) Wächtler, H.; Pena Fuentes, D.; Quincoces Suarez, J. A.; Michalik, D.; Villinger, A.; Kragl, U.; Vogel, C.
A versatile approach to novel homo-C-nucleosides based on aldehydes and acetylenic ketones derived from ribo- and 2-deoxy-ribofuranose C-glycosides
ARKIVOC 2012, 110-133 (2012)

(144) Neubauer, K.; Hühns, M.; Hausmann, T.; Klemke, F.; Lockau, W.; Kahmann, U.; Pistorius, E. K.; Kragl, U.; Broer, I.
Isolation of cyanophycin from tobacco and potato plants with constitutive plastidic cphATe gene expression
Journal of Biotechnology 158, 50–58 (2012)



(143) Wenda, S.; Illner, S.; Mell, A.; Kragl, U.
Industrial biotechnology – the future of green chemistry?
Green Chemistry 13, 3007-3047 (2011)

(142) Engel N.; Oppermann C.; Falodun A.; Kragl U.
Proliferative effects of traditional Nigerian medicinal plant extracts on human breast and bone cancer cell lines
Journal of Ethnoparmacology 137, 1003-1010 (2011)

(141) Schmidt, K.; Höflich, C.; Bruch, M.; Entzian, K.; Kacholdt, A.; Kragl, U.; Leinweber, P.; Mikschofsky, H.; Mönkemeyer, W.; Neubauer, K.; Schlichting, A.; Schmidtke, J.; Steinmann, A.; Stryzna-Schulze, C.; Wilhelm, R.; Ziegler, A.; Broer, I.
BioOK – a comprehensive system for analysis and risk assessment of genetically modified plants
Journal for Cultivated Plants 63, 232-248 (2011)

(140) Wächtler, H.; Pena Fuentes, D.; Michalik, D.; Köckerling, M.; Villinger, A.; Kragl, U.; Arias Cedeno, Q.; Vogel, C.
A versatile approach to alcohol, aldehyde, ketone and amine derivatives starting from b-allyl C-glycosides of D-ribofuranose and 2-deoxy-D-ribofuranose
Synthesis, 3099-3108 (2011)

(139) Mell, A., Kragl, U.
Ionic Liquids
in M. Moo-Young (ed.) Comprehensive Biotechnology, 2nd ed., Vol. 2, p 999-1006, Elsevier, Amsterdam (2011)

(138)  Plagemann, R.; Jonas, L.; Kragl, U.
Ceramic honeycomb as support for covalent immobilization of laccase from Trametes versicolor and transformation of nuclear fast red
Applied Microbiology and Biotechnology 90, 313-320 (2011)

(137) Oppermann, S.; Stein, F.; Kragl, U.
Ionic liquids for two phase systems and their application for purification, extraction and biocatalysis
Applied Microbiology and Biotechnology 89, 493-499 (2011)

(136) Neubert, L.; Paetzold, E.; Fischer, C.; Kempers, P.; Schörken, U.; Schümann, U.; Sadlowski, T.; Beller, M.; Kragl, U.
Neuartige Kraftstoffadditive: Herstellung von Acetalen aus Glycerin und Olefinen
Chemie-Ingenieur-Technik 83, 1–10 (2011)



(135) Duwensee, J.; Wenda, S.; Ruth, W; Kragl, U.
Lipase-Catalyzed Polycondensation in Water: A New Approach for Polyester Synthesis
Organic Process Research & Development, 14, 48-57 (2010)



(134) von Langermann, J.; Mell, A.; Paetzold, E.; Kragl, U.
Hydroxynitrile lyase catalysed synthesis of enantiopure (S)-acetophenone cyanohydrins
in J. Whittal & Peter W. Sutton (Editors) "Practical Methods in Biocatalysis and Biotransformations", John Wiley & Sons Ltd (2009), Chichester, pp 262-265

(133) Hühns, M.; Neumann, K.; Hausmann, T.; Klemke, F.; Lockau, W.; Kahmann, U.; Kopertekh, L.; Staiger, D.; Pistorius, E. K.; Reuther, J.; Waldvogel, E.; Wohlleben, W.; Effmert, M.; Junghans, H.; Neubauer, K.; Kragl, U.; Schmidt, K.; Schmidtke, J.; Broer, I.
Tuber-specific cphA expression to enhance cyanophycin production in potatos
Plant Biotechnology Journal 7, 883-898 (2009)

(132) Guterl, J. K.; Andexer, J. N.; Sehl, T.; von Langermann, J.; Frindi-Wosch, I.; Rosenkranz, T.; Fitter, J.; Gruber, K.; Kragl, U.; Eggert, T.; Pohl, M.
Uneven Twins: Comparison of two Hydroxynitrile Lyases with α/β-Hydrolase Fold.
Journal of Biotechnology, 3-4, 166-173 (2009)

(131) Izak P.; Friess K.; Hynek V.; Ruth W.; Fei Z.; Dyson J.P.; Kragl U.
Separation Properties of Supported Ionic Liquid-Polydimethylsiloxane Membrane in Pervaporation Process.
Desalination 241(1-3), 182-187 (2009)

(130) Andexer, J.; von Langermann, J.; Kragl, U.; Pohl, M.
How to overcome limitations in biotechnological processes: examples from hydroxynitrile lyase applications
Trends in Biotechnology, 27, 599-607 (2009)

(129) Fritz, R.; Ruth, W.; Kragl, U.
Assessment of acetone as an alternative to acetonitrile in peptide analysis by liquid chromatography-mass spectrometry.
Rapid Communications in Mass Spectrometry, 23, 2139-2145 (2009)

(128) Dreyer, S.; Salim, P.; Kragl, U.
Driving forces of protein partitioning in an ionic liquid-based aqueous two-phase system
Biochemical Engineering Journal 46, 176-185 (2009)

(127) Kumar, S.; Kumar, M.; Thurowb, K.; Stoll, R.; Kragl, U.
Fuzzy Filtering for Robust Bioconcentration Factor Modelling
Environmental Modelling & Software, 24, (2009), 44-53

(126) Verevkin, S. P.; Emelyanenko, V. N.; Toktonov, A. V.; Leolko, A. S.; Duwensee, J.; Kragl, U.; Sarge, S. M.
Thermochemical and Ab Initio Studies of Biodiesel Fuel Surrogates: 1,2,3-Propanetriol Triacetate, 1,2-Ethanediol Diacetate, and 1,2-Ethanediol Monoacetate
Industrial and Engineering Chemistry Research 48, 7388-7399 (2009)



(125) Horn, A.; Kumar, S.; Liese, A.; Kragl, U.
Reactions on Immobilized Biocatalysts in in Ertl, Knözinger, Schüth (eds.)
Handbook of Heterogeneous Catalysis, 2nd ed.
VCH Weinheim, pp. 3831-3865 (2008)

(124) Eisenhut, M.; Ruth, W.; Haimovich, M.; Bauwe, H.; Kaplan, A.; Hagemann, M.
The photorespiratory glycolate metabolism is essential for cyanobacteria and might have been conveyed endosymbiontically to plants.
Proceedings of the National Academy of Sciences of the United States of America 105, 17199-17204 (2008)

(123) Schlichl, D.A.; Enthaler, S.; Holla, W.; Riermeier, T.; Kragl, U.; Beller, M.
Dynamic Kinetic Resolution of a-Amino Acid Esters in the Presence of Aldehydes
Eur. J. Org. Chem. (2008), 3506-3512

(122) Izak, P.; Ruth, W.; Fei, Z.; Dyson, PJ.; Kragl, U.
Selective removal of acetone and butan-1-ol from water with supported ionic liquidpolydimethylsiloxane membrane by pervaporation
Chemical Engineering Journal, 139, (2008), 318 –321

(121) Zimmermann, V.; Masuck, I., Kragl, U.
Reactive extraction of N-acetylneuraminic acid - Kinetic model and simulation of integrated
product removal
Separation and Purification Technology, 63, (2008), 129-137

(120) Zimmermann, V.; Kragl, U.
Reactive extraction of N-acetylneuraminic acid - A new method to
recover neuraminic acid from reaction solutions
Separation and Purification Technology, 61, (2008), 64–71

(119) Izak, P.; Schwarz, K.; Ruth, W.; Bahl, H.; Kragl, U.
Increased productivity of Clostridium acetobutylicum fermentation of acetone, butanol, and ethanol by pervaporation through supported ionic liquid membrane
Applied Microbiology and Biotechnology, 78, 2008, 597-602

(118) Dreyer, S.; Kragl, U.
Ionic liquids for aqueous two phase extraction and stabilisation of enzymes.
Biotechnology and Bioengineering, 99, (2008), 1416-1424

(117) von Langermann, J.; Guterl, J-K.; Pohl, M.; Wajant, H.; Kragl, U.
Hydroxynitrile lyase catalyzed cyanohydrin synthesis at high pH-values.
Bioprocess Biosyst Eng, 31, (2008), 155–161



(116) Kumar, S.; Kumar, M.; Stoll, R.; Kragl, U.
Handling uncertainties in toxicity modelling using a fuzzy filter.
SAR and QSAR in Environmental Research, 18, Issue 7 & 8 (2007), 645 - 662

(115) Andexer, J.; von Langermann, J.; Mell, A.; Bocola, M.; Kragl, U.; Eggert, T.; Pohl, M.
A new (R)-selective Hydroxynitrile Lyase from Arabidopsis thaliana with an alpha/beta- Hydrolase fold.
Angewandte Chemie - International Edition 46, 8679 - 8681 (2007)

(114) Höpfner, D.; Przymusinski, S.; Kragl, U.
Keramikmembranen in der Begasung flüssiger Medien
Verfahrenstechnik, 10, 48-49 (2007)

(113) Abarzua, S.; Szewczyk, M.; Gailus, S.; Richter, D.-U.; Ruth, W.; Briese, V.; Piechulla, B.
Effects of Phytoestrogen Extracts from Linum usitatissimum on the Jeg3 Human Trophoblast Tumour Cell Line
Anticancer Research, 27, 2053-2058 (2007)

(112) Ludwig, R.; Kragl, U.
Do We Understand the Volatility of Ionic Liquids?
Angewandte Chemie – International Edition, 46, 6582-6584 (2007)

(111) Zimmermann, V.; Hennemann, H.-G.; Daußmann, T.; Kragl, U.
Modelling the reaction course of N-Acetylneuraminic acid synthesis from N-Acetyl-Dglucosamine – New strategies for the optimisation of Neu5Ac Synthesis
Applied Microbiology and Biotechnology, 76, 597-605 (2007)

(110) Schütz, C.; Dwars, T.; Schnorpfeil, C.; Radnik, J.; Menzel, M.; Kragl, U.
Selective Polymerization of Propylene Oxide by a Tin-Phosphate Coordination Polymer
Journal of Polymer Science Part A: Polymer Chemistry, 45, 3032-3041 (2007)

(109) Klembt, S.; Dreyer, S. Eckstein; M; Kragl, U.
Biocatalytic reactions in ionic liquids in Wasserscheid, P.; Welton, T. (eds.) Ionic Liquids in Synthesis 2nd Ed.; Wiley-VCH Weinheim, pp. 641-661 (2007)

(108) Lütz, S.; Kragl, U.; Liese, A.; Wandrey, C.
Reaction engineering in asymmetric catalysis
in Enders, Jaeger (Ed.) Asymmetric Synthesis with Chemical and Biological Methods; Wiley
VCH, Weinheim, pp 415-427 (2007)

(107) von Langermann, J.; Mell, A.; Paetzold, E; Daußmann, T; Kragl, U.
Hydroxynitrile lyase in organic solvent free systems to overcome thermodynamic limitations
Advanced Synthesis and Catalysis, 349, 1418-1424 (2007)



(106) Izak, P.; Koekerling, A.; Kragl, U.
Solute transport from aqueous mixture throught supported ionic liquid membrane by pervaporation
Desalination, 199, 96-98 (2006)

(105) Witzke, T.; Kolitsch, U.; Krause, W.; Wiechowski, A.; Medenbach, O.; Kampf, A.; Steele, I.; Favreau, G.
Guanacoite, Cu2Mg2(Mg0.5Cu0.5)(OH)4(H2O)4(AsO4)2, a new arsenate mineral species from the El Guanaco Mine, near Taltal, Chile: Description and crystal structure
European Journal of Mineralogy, 18, 813-821 (2006)

(104) Schütz, C.; Dwars, T.; Kragl, U.
Investigation on the Biocatalytic Oligomerization of Glycidol
Letters in Organic Chemistry 3, 679-684 (2006)

(103) Izak, P.; Köckerling, M.; Kragl, U.
Stability and selectivity of multiphase membrane, consisting of dimethylpolysiloxane on an ionic liquid, used in the separation of solutes from aqueous mixture by pervaporation
Green Chemistry 8, 947-948 (2006)

(102) Matscheski, A.; Richter, D.-U.; Hartmann, A.-M.; Effmert, U.; Jeschke, U.; Kupka, M.S.; Abarzua, S.; Briese, V.; Ruth, W.; Kragl, U.; Piechulla, B.
Effects of Phytoestrogen Extracts Isolated from Rye, Green and Yellow Pea Seeds on Hormone Production and Proliferation of Trophoblast Tumor Cells Jeg3
Hormone Research 65, 276–288 (2006)

(101) Eckstein, M.F.; Peters, M.; Lembrecht, J.; Spiess, A.; Greiner, L.
Maximise equilibrium conversion in biphasic catalysed reactions: Mathematical description
and practical guideline.
Advanced Synthesis & Catalysis 348, 1591-1596 (2006)

(100) Eckstein, M.F.; Lembrecht, J.; Schumacher, J.; Eberhard, W.; Spiess, A.; Peters, M.; Roosen, C.; Greiner, L.; Leitner, W.; Kragl, U.
Maximise your equilibrium conversion in biphasic catalysed reactions: How to obtain reliable data for equilibrium constants?
Advanced Synthesis & Catalysis 348, 1597-1604 (2006)

(99) Schumacher, J.; Eckstein, M.; Kragl, U.
Influence of water-miscible organic solvents on kinetics and enantioselectivitiy of the (R)-
specific alcohol dehydrogenase from Lactobacillus brevis
Biotechnology Journal 1, 574-581 (2006)

(98) Dreyer, S.; Lembrecht, J.; Schumacher, J., Kragl, U.
Enzyme catalysis in non-aqueous media – past-present-future
in R. Patel (Ed.) Biocatalysis in the Pharmaceutical and Biotechnology Industries (2006),
CRC-Press, Taylor & Francis Group, Boca Raton, pp 791-828

(97) Kumar, S.; Ruth, W.; Sprenger, B.; Kragl, U.
On the biodegradation of ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate
Chimica Oggi/Chemistry today 24, 24-26 (2006)

(96) Zimmermann, V.; Beller, M.; Kragl, U.
Modelling the reaction course of a dynamic kinetic resolution of amino acid derivatives: Identifying and overcoming bottlenecks
Organic Process Research & Development 10, 622-627 (2006)

(95) Hameister, D.; Kragl, U.
Selective recovery of carbohydrates from aqueous solution facilitated by a carrier
Engineering in Life Sciences 6, 187-192 (2006)



(94) Waldschläger, J.; Bergemann, C.; Ruth, W.; Effmert, U. Jeschke, U.; Richter, D. U.; Kragl, U.; Piechulla, B.; Briese, V.
Flax-seed extracts with phytoestrogenic effects on a hormone receptor-positive tumor cell line
Anticancer Res. 25, 1817-1822 (2005)

(93) Miethchen, R.; Schmidt A.; Neitzel, K.; Michalik, M.; Pundt, T.; Ruth, W.
Concentrated Hydriodic Acid in Simultaneous Deprotections of Multifunctional Inositols
Carbohydr. Res. 340, 741-748. (2005)

(92) Kragl, U., Faust, U.
Mikrobiologische Herstellung chemischer Grundstoffe
in Winnacker-Küchler: Chemische Technik – Prozesse und Produkte, 5. Aufl. Band 5 Organische Zwischenverbindungen, Polymere (Eds. R. Dittmeyer, W. Keim, G.
Kreysa, A. Oberholz), Wiley-VCH, Weinheim, pp 1377-1416 (2005)

(91) Dorbritz, S.; Ruth, W.; Kragl, U.
Investigation on aggregate formation of ionic liquids
Adv. Synth. Cat. 347, 1273-1279 (2005)

(90) Vogl, C.; Paetzold, E.; Fischer, C.; Kragl, U.
Highly selective hydroformylation of intern and terminal olefines to terminal aldehydes using a rhodium-BIPHEPHOS-catalyst system
J. Mol Cat. A. 232, 41-44 (2005)

(89) Dwars, T.; Paetzold, E.; Oehme, G.
Reactions in micellar systems
Angew. Chem. 117, 7338-7364 (2005)
Angew. Chem. Int. Ed. 44, 7174-7199 (2005)



(88) Pfründer, H.; Amidjojo. M.; Kragl, U.; Weuster-Botz. D.
Efficient whole cell biotransformation in a biphasic ionic liquid/water system
Angew. Chem. 116, 4629-4631 (2004).
Angew. Chem. Int. Ed. 43, 4529-4531 (2004)

(87) Eckstein, M.; Daußmann, T.; Kragl, U.
Recent developments in NAD(P)H regeneration for enzymatic reduction in one- and twophase systems
Biocatalysis & Biotransformation 22, 89-96 (2004)

(86) Eckstein, M.; Villela Filho, M.; Liese, A.; Kragl, U.
Use of an ionic liquid in a two-phase system to improve an alcohol dehydrogenase catalysed reduction
Chem. Comm., 1084-1085 (2004)

(85) Paetzold, E.; Oehme G.; Jovel, I.
Enviromentelly benign Suzuki reaction in multi phase systems promoted by supported detergents
J. Mol. Catal. A: Chemical 214, 241-247 (2004)

(84) Kaftzik, N.; Kroutil, W.; Faber, K.; Kragl, U.
Mandelate Racemase Activity in Ionic Liquids: Scopes and Limitations
J. Mol. Cat. A: Chemical 214, 107-112 (2004)

(83) Reyes, A.; Lafuente, C.; Minones Jr., J.; Kragl, U.; Royo, F. M.
(Vapor + liquid) equilibrium of binary mixtures (1,3-dioxolane or 1,4-dioxane + 2-methyl-1-propanol or 2-methyl-2-propanol) at isobaric conditions
J. Chem. Thermodynamics 36, 87-93 (2004)

(82) Strübing, D.; Neumann, H.; Klaus, S.; von Wangelin, A. J.; Gördes, D.; Beller, M.; Braiuca, P.; Ebert, C.; Gardossi, L.; Kragl, U.
Enzymatic resolution of 4-N-phenylacetylamino-derivatives obtained from multicomponent reactions using using PenG Amidase and in silico studies
Tetrahedron 60, 683-691 (2004)



(81) Kragl, U.
in Baerns, M. (Ed) Basic Principles in Applied Catalysis, Springer Verlag, Berlin, pp 443-452 (2003)

(80) Oehme, G.; Paetzold, E.; Fischer, C.; Frank, M.
Phosphinoethyl-sulfonatoalkylthioethers and diphenyl-ω -sulfonatoalkylphosphines as ligands
and polyoxyethylene-polyoxy-propylene- polyoxyethylene triblock co-polymers as promoters in the rhodium-catalyzed hydroformylation of 1-dodecene in aqueous two-phase systems
Journal of Molecular Catalysis A: Chemical 200, 95-103 (2003)

(79) Kröckel, J., Kragl, U.
Nanofiltration for the separation of non-volatile products from solutions containing ionic liquids
Chem. Eng. Tech. 26, 1166-1168 (2003)

(78) Oehme, G.; Grassert, I.; Paetzold E.; Fuhrmann, H.; Dwars T.; Schmidt U.; Jovel I.
The Effect of Assembled Amphiphiles on Catalytic Reactions in Aqueous Media
Catalysis (Translation of Kinetika i Kataliz) 44, 766-777 (2003)
Влияние агрегированных амфифилов на каталитические реакции в водной среде
Кинетика и катализ 44, 1-13 (2003)

(77) Kaftzik, N.; Neumann, S.; Kula, M.-R.; Kragl, U.
Enzymatic Condensation Reactions in Ionic Liquids
in: Ionic Liquids as Green Solvents: Progress and Prospects, Eds. R. D. Rogers, D. R. Estill
ACS Symposium Series 856, 206-212 (2003)

(76) Dwars, T.; Fuhrmann, H.; Ehlbeck, J.; Maaß, M.; Oehme, G.
A new low-temperature plasma discharge reactor for poymerisation of unsaturated compounds
Surf. Coat. Technol. 174-175, 597-600 (2003)

(75) Kröckel, J.; Kragl, U.
Nanofiltration zur Aufarbeitung von schwerflüchtigen Produkten aus Lösungen mit ionischen Flüssigkeiten
Chem. Ing. Tech. 75, 959-961 (2003)

(74) Vasic-Racki, D.; Kragl, U.; Liese A.
Benefits of enzyme kinetics modelling
Chemical and Biochemical Engineering Quarterly 17, 7-18 (2003)

(73) Gallego, R. G.; Dudziak, G. Kragl, U.; Wandrey, C.; Kamerling, J. P.; Vliegenthart, J. F. G.
Enzymatic Synthesis of the core-2 sialyl lewis X O-glycan on the tumor associated MUC1a´peptide
Biochimie 85, 275-286 (2003)

(72) Pilz, R.; Hammer, E.; Schauer, F.; Kragl, U.
Laccase-catalysed synthesis of coupling products of phenolic substrates in different reactors
Applied Microbiology and Biotechnology 60, 708-712 (2003)

(71) Fuhrmann, H.; Dwars, T.; Michalik, D.; Holzhüter, G.; Grüttner, C.; Kragl, U.; Oehme, G.
Asymmetric hydrogenation in a membrane reactor. Catalyst encapsulation and substrate solubilization in polymer-surfactant complexes
Advanced Synthesis & Catalysis 345, 202-210 (2003)

(70) Fuhrmann, H.; Dwars, T.; Oehme, G.
Wasser als Lösungsmittel
Chemie in unserer Zeit 37, 40-50 (2003)



(69) Kragl, U. Eckstein, M; Kaftzik, N.
Biocatalytic reactions in ionic liquids
in Wasserscheid, P.; Welton, T. (eds.)
Ionic Liquids in Synthesis
Wiley-VCH Weinheim, pp. 336-347 (2002)

(68) Kragl, U.; Eckstein, M.; Kaftzik, N.
Enzyme catalysis in ionic liquids
Current Opinion in Biotechnology 13, 565-571 (2002)

(67) Kaftzik, N.; Wasserscheid, P.; Kragl, U.
Use of Ionic Liquids to Increase the Yield and Enzyme Stability in the b-Galactosidase Catalysed Synthesis of N-Acetyllactosamine
Organic Process Research & Development 6, 553-557 (2002)

(66) Kragl, U.; Dreisbach, C.
Membrane Reactors in Homogeneous Catalysis
in Cornils, B., Herrmann W. A. (eds.)
Applied Homogeneous Catalysis with Organometallic Compounds, 2nd Edition
Wiley-VCH Weinheim, pp. 941-952 (2002)

(65) Biselli, M.; Kragl, U.; Wandrey, C.
Reaction Engineering for Enzyme-Catalyzed Biotransformations
in Drauz, K., Waldmann, H. (eds.): Enzyme Catalysis in Organic Synthesis, 2nd Edition
Wiley-VCH Weinheim, pp. 185-257 (2002)

(64) Eckstein, M.; Sesing, M.; Kragl, U.; Adlercreutz, P.
At low water activity a-chymotrypsin is more active in an ionic liquid than in non-ionic organic solvents
Biotechnology Letters 24, 867-872 (2002)

(63) Eckstein, M.; Wasserscheid, P.; Kragl, U.
Enhanced enantioselectivity of lipase from Pseudomona sp. at high temperatures and fixed water activity in the ionic liquid 1-butyl-3-methyl bis((trifluoromethyl)sulfonyl)amide
Biotechnology Letters 24, 763-767 (2002)

(62) Liese, A.; Kragl, U.; Kierkels, H.; Schulze, B.
Membrane reactor development for the kinetic resolution of ethyl 2-hydroxy-4-phenylbutyrate
Enzyme Microbiol. Technology 30, 673-681 (2002)



(61) Kragl, U.; Dwars, T.
The development of new methods for the recycling of chiral catalysts
Trends in Biotechnology 19, 442-449 (2001)

(60) Kragl, U.; Kaftzik, N.; Schöfer, S. H.; Eckstein, M., Wasserscheid, P.; Hilgers, C.
Enzyme catalysis in the presence of ionic liquids
Chemistry today 19 (7/8), 22-24 (2001)

(59) Schwarz-Linek, U.; Krödel, A.; Ludwig, F.-A.; Schulze, A.; Rissom, S.; Kragl, U.; Tishkov, V.I.; Vogel, M.
Synthesis of natural product precursors by Baeyer-Villiger Oxidation with cyclohexanone monooxygenase from Acinetobacter
Synthesis, 947-951 (2001)

(58) Dwars, T.; Haberland, J.; Grassert, I.; Oehme, G; Kragl, U.
Asymmetric Hydrogenation in a Membrane Reactor: Recycling of the Chiral Catalyst by Using a Retainable Micellar System
Journal of Molecular Catalysis A 168, 81-86 (2001)

(57) Schöfer, S. H.; Kaftzik, N.; Wasserscheid, P.; Kragl; U.
Enzyme Catalysis in Ionic Liquids: Lipase Catalyzed Kinetic Resolution of 1-Pheylethanol with Improved Enantioselectivity
Chem. Comm., 425-426 (2001)



(56) Kleij, A. W.; Gossage, R. A.; Klein Gebbink, R. J. M.; Brinkmann, N.; Reijerse, E. J.; Kragl, U.; Lutz, M.; Spek, A. L.; van Koten, G.
A „ dendritic effect“ in homogeneous catalysis with carbosilane-supported arylnickel(II) catalysts: Observation of active-site proximity effects in atom-tranfer radical addition
J. Am. Chem. Soc. 122, 12112-12124 (2000)

(55) Watt, G. M.; Flitsch, S. L.; Fey, S.; Elling, L.; Kragl, U.
The preparation of deoxy derivatives of mannose-1-phosphate and their substrate specificity towards recombinant GDP-mannose pyrophosphorylase from Salmonella enterica, group B
Tetrahedron Asymmetry 11, 621-628 (2000)

(54) Kula, M.-R.; Kragl, U.
Dehydrogenases in the synthesis of chiral compounds
in Stereoselective Biocatalysis; Patel, R. N. (Ed),
Marcel Dekker, New York, pp 839-866 (2000)



(53) Creemers, A. F.; Klaassen, C. H. W.; Bovee-Geurts, P. H. M.; Kelle, R.; Kragl, U.; Raap, J.; de Grip, W. J.; Lugtenburg, J.; de Groot, H. J. M.
15N Solid state NMR evidence for a Schiff base counterion in the visual G-protein coupled receptor rhodopsin
Biochemistry 38, 7195-7199 (1999)

(52) Raap, J.; Niewenhuis, S.; Creemers, A.; Hexspoor, S.; Kragl, U.; Lugtenburg, J.
Synthesis of isotopically labelled L-phenylalanine and L-tyrosine
Eur. J. Org. Chem., 2609-2621 (1999)

(51) Kragl, U.; Liese, A.
Biotransformations, Engineering Aspects
in Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis & Bioseparation
Flickinger, M. C.; Drew, S. W. (eds.); John Wiley & Sons, 454-464 (1999)

(50) Kragl, U.; Greiner, L.; Wandrey, C.
Enzymes, immobilized, reactors
in Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis & Bioseparation
Flickinger, M. C.; Drew, S. W. (eds.); John Wiley & Sons, 1064-1074 (1999)

(49) Hovestad, N. L.; Eggeling, E. B.; Heidbüchel, H. J.; Jastrzebski, J. T. B. H.; Kragl, U.; Keim, W.; Vogt, D.; van Koten, G.
Selective hydrovinylation of styrene with multisite Pd-catalysts using carbosilane dendrimers functionalized with hemilabile P,O-ligands in a membrane reactor
Angewandte Chemie 111, 1763-1765 (1999); Angew. Chem. Int. Ed. Engl. 38, 1655-1658

(48) Brinkmann, N.; Giebel, D.; Lohmer, G.; Reetz, M. T., Kragl, U.
Allylic substitution with dendritic palladium catalysts in a continuously operating membrane
Journal of Catalysis 183, 163-168 (1999)

(47) Rissom, S.; Beliczey, J.; Giffels, G.; Kragl, U.; Wandrey, C.
Asymmetric reduction of acetophenone in membrane reactors: comparison of
oxazaborolidine and alcohol dehydrogenase catalyzed process
Tetrahedron: Asymmetry 10, 923-928 (1999)

(46) Dudziak, G.; Fey, S.; Hasbach, L.; Kragl, U.
Nanofiltration for purification of nucleotide sugars
Journal of Carbohydrate Chemistry 18, 41-49 (1999)



(45) Dudziak, G.; Zeng, S.; Berger, E. G.; Gallego, R. G.; Kamerling, J.; Kragl, U.; Wandrey, C.
In situ generated O-glycan core 1 structure as substrate for Gal(b1-3)GalNAcb-1,6-GlcNAc transferase
Bioorganic & Medicinal Chemistry Letters 8, 2595-2598 (1998)

(44) Vasic-Racki, Dj.; Kragl, U.; Conrad, D.; Wandrey, C.
Modelling of yeast alcohol dehydrogenase catalysed production of chiral alcohols
Chemical and Biochemical Engineering Quarterly 12, 87-95 (1998)

(43) Kragl., U.; Beliczey, J.; Brinkmann, N.; Felder, M.; Giffels, G.; Wandrey, C.
Membranreaktoren in der organischen Synthese
VDI-GVC-Jahrbuch 1998, 151-166 (1998)

(42) Giffels, G.; Beliczey, J.; Felder, M.; Kragl, U.
Polymer enlarged oxazaborolidines in a membrane reactor: enhancing effectivity by retention of the homogeneous catalyst
Tetrahedron: Asymmetry 9, 691-696 (1998)

(41) Liese, A.; Zelinsky, T.; Kula, M.-R.; Kierkels, H.; Karutz, M.; Kragl, U.; Wandrey, C.
A novel reactor concept for the enzymatic reduction of poorly soluble ketones
Journal of Molecular Catalysis: B Enzymatic 4, 91-99 (1998)



(40) Fey, S.; Elling, L.; Kragl, U.
The cofactor Mg2+ - a key switch for effective continuous enzymatic production of GDPmannose using recombinant GDP-mannose pyrophosphorylase
Carbohydrate Research 305, 475-481 (1997)

(39) Beliczey, J.; Kragl, U.
From chitin to N-acetylneuraminic acid - N-acetylglucosamine as intermediate in Muzzarelli, R. A. A.; Peter, M. G. (eds.)
Chitin Handbook
European Chitin Society, pp. 221-226 (1997)

(38) Salagnad, C.; Gödde, A.; Ernst, B.; Kragl, U.
Enzymatic large scale production of 2-keto-3-deoxy-D-glycero-D-galactononulopyranosonic acid (KDN) in enzyme membrane reactors
Biotechnology Progress 13, 810-813 (1997)

(37) Rissom, S.; Schwarz-Linek, U.; Vogel, M.; Tishkov, V.I.; Kragl, U.
Synthesis of chiral e-lactones in a two-enzyme system of cyclohexanone monooxygenase and formate dehydrogenase with integrated bubble-free aeration
Tetrahedron: Asymmetry 8, 2523-2526 (1997)

(36) Seelbach, K.; van Deurzen, M. P. J.; van Rantwijk, F.; Sheldon, R. A.; Kragl, U.
Improvement of the total turnover number and space-time yield for chloroperoxidase catalyzed oxidation
Biotechnol. Bioeng. 55, 283-288 (1997)

(35) Kragl, U.; Wandrey, C.
Biocatalytic Reactions with Immobilized Enzymes
in Ertl, Knözinger, Weitkamp (eds.)
Handbook of Heterogeneous Catalysis
VCH Weinheim, pp. 2436-2447 (1997)

(34) Beliczey, J.; Giffels, G.; Kragl, U.; Wandrey, C.
Novel ligands derived from S-tyrosine for the enantioselective addition of diethylzinc to aldehydes
Tetrahedron: Asymmetry 8, 1529-1530 (1997)

(33) van Deurzen, M. P. J.; Seelbach, K.; van Rantwijk, F.; Kragl, U.; Sheldon, R. A.
Chloroperoxidase: use of a hydrogen peroxide-stat for controlling reactions and improving enzyme performance
Biocatalysis and Biotransformation 15, 1-16 (1997)

(32) Bongs, J.; Hahn, D.; Schörken, U.; Sprenger, G. A.; Kragl, U.; Wandrey, C.
Continuous production of carbohydrates using a transketolase in a membrane reactor
Biotechnology Letters 19, 213-215 (1997)

(31) Seelbach, K.; Kragl, U.
Nanofiltration Membranes for Cofactor Retention in Continuous Enzymatic Synthesis
Enzyme Microbiol. Technol. 20, 389-392 (1997)

(30) Range, G.; Krähmer, R.; Welzel, P.; Müller, D.; Herrmann, G. F.; Kragl, U.; Wandrey, C.; Markus, A.; Heijenoort, Y. van, Heijenoort, J. van
A chemoenzymatic approach towards moenomycin structural analogues
Tetrahedron 53, 1695-1706 (1997)



(29) Kragl, U.; Klein, T.; Vasic-Racki, D.; Kittelmann, M.; Ghisalba, O.; Wandrey, C.
Reaction engineering aspects of activated sugar production - CMP-Neu5Ac as example
Ann. N. Y. Acad. Sci. 799, 577-583 (1996)

(28) Kragl, U.; Kruse, W.; Hummel, W.; Wandrey, C.
Enzyme Engineering Aspects of Biocatalysis: Cofactor Regeneration as Example
Biotechnol. Bioeng. 52, 309-319 (1996)

(27) Kragl, U.; Dreisbach, C.; Wandrey, C.
Membrane Reactors in Homogeneous Catalysis
in Cornils, B., Herrmann W. A. (eds.)
Applied Homogeneous Catalysis with Organometallic Compounds
VCH Weinheim, pp. 832-843 (1996)

(26) Liese, A.; Karutz, M.; Kamphuis, J.; Wandrey, C.; Kragl, U.
Enzymatic Resolution of 1-Phenyl-1,2-ethanediol by Enantioselective Oxidation: Overcoming Product Inhibition by Continuous Extraction.
Biotechnol. Bioeng. 51, 544-550 (1996)

(25) Malissard, M.; Borsig, L.; Di Marco, S.; Grütter, M. G.; Kragl, U.; Wandrey, C.; Berger, E.
G.; Recombinant soluble b-1,4-galactosyltransferases expressed in Saccharomyces cerevisiae: purification, characterization and comparision with human enzyme
Eur. J. Biochem. 239, 340-348 (1996)

(24) Kragl, U.
Enzyme Membrane Reactors
in Godfrey, T.; West, S. (eds.)
Industrial Enzymology - Application of Enzymes in Industry
2nd Edition, 1996, Macmillan, London, pp 271-283

(23) Seelbach, K.; Riebel, B.; Hummel, W.; Kula, M.-R.; Tishkov, V. I.; Egorov, E.M.; Wandrey, C.; Kragl, U.
A Novel, Efficient Regenerating Method of NADPH Using a New Formate Dehydrogenase.
Tetrahedron Lett. 37, 1377-1380 (1996)

(22) Kragl, U.; Dreisbach, C.
Kontinuierliche asymmetrische Synthese in einem Membranreaktor
Angew. Chem. 108, 684-685 (1996)
Angew. Chem. Int. Ed. Engl. 35, 642-644 (1996)

(21) Kruse, W.; Hummel, W.; Kragl, U.
Alcohol Dehydrogenase Catalyzed Production of Chiral, Hydrophobic Alcohols: A New Approach Leading to a Nearly Wasteless Process
Recl. Trav. Chim. Pays-Bas 115, 239-243 (1996)

(20) Kragl, U.; Vasic-Racki, Dj.; Wandrey, C.
Continuous Production of L-tert-leucine in series of two enzyme membrane reactors. Modelling and computer simulation.
Bioprocess Engineering 14, 291-297 (1996) 



(19) Giffels, G.; Dreisbach, C.; Kragl, U.; Weigerding, M.; Waldmann, H.; Wandrey, C.
Chirale Titanalkoxide als Katalysatoren zur enantioselektiven Reduktion von Ketonen mit Boranen
Angew. Chem. 107, 2165- 2166 (1995)
Angew. Chem. Int. Ed. Engl. 34, 2005-2006 (1995)

(18) Borsig, L.; Ivanov S. X.; Herrmann, G. F.; Kragl, U.; Wandrey, C.; Berger, E. G.
Scaled Up Expression of Human a2,6(N)Sialyltransferase in Saccharomyces cerevisiae
Biochem. Biophys. Res. Comm. 210, 14-20 (1995)

(17) Kittelmann, M.; Klein, T.; Kragl, U.; Wandrey, C.; Ghisalba, O.
CMP-Neuraminic Acid Synthetase from Escherichia coli: Fermentative Production and Application for the Preparative Synthesis of CMP-Neuraminic Acid
Appl. Microbiol. Biotechnol., 44, 59-67 (1995)

(16) Kragl, U.; Kittelmann, M.; Ghisalba, O.; Wandrey, C.
N-Acetylneuraminc Acid: from a Rare Chemical isolated from Natural Sources to a
Multikilogram Enzymatic Synthesis for Industrial Application
Ann. N. Y. Acad. Sci. 750, 300-305 (1995)

(15) Biselli, M.; Kragl, U.; Wandrey, C.
Reaction Engineering for Enzyme-Catalyzed Biotransformations
in Drauz, K., Waldmann, H. (eds.) Handbook of Enzyme Catalysis in Organic Synthesis VCH Weinheim, pp. 89-155 (1995)

(14) Dreisbach, C.; Wischnewski, G.; Kragl, U.; Wandrey, C.
Changes of Enantioselectivity with the Substrate Ratio for the Addition of Diethylzinc to Aldehydes Using a Catalyst Coupled to a Soluble Polymer
J. Chem. Soc., Perkin Trans. 1, 875-878 (1995)

(13) Herrmann, G. F.; Krezdorn, C.; Malissard, M.; Kleene, R.; Paschold, H.; Weuster-Botz, D.; Kragl, U.; Berger, E. G.; Wandrey, C.
Large Scale Production of a Soluble Human a-1,4-Galactosyltransferase using a Saccharomyces cerevisiae Expression System
Prot. Expr. Purific., 6 (1), 72-78 (1995) 

vor 1995

vor 1995

(12) Dreisbach, C.; Kragl, U.; Wandrey, C.
(1S,2R,3R,4R)-a, a,a', a'-Tetraphenyl-bicyclo[2.2.1]heptane-2,3-dimethanol and Its
Enantiomer as Ligands in Titanate-Complex-Catalyzed Diethylzinc Addition to Aldehydes
Synthesis, 911-912 (1994)

(11) Kragl, U.; Gödde, A.; Wandrey, C.; Lubin, N.; Augé, C.
New Synthetic Applications of Sialic Acid Aldolase, a Useful Catalyst for KDO Synthesis. Relation between Substrate Conformation and Enzyme Stereoselectivity.
J. Chem. Soc., Perkin Trans. 1, 119-124 (1994)

(10) Herrmann, G.; Kragl, U., Wandrey, C.
Kontinuierliche katalytische Herstellung von N-Acetyllactosamin
Angew. Chem., 105, 1399-1400 (1993)
Angew. Chem. Int. Ed. Engl., 32, 1342-1343 (1993)

(9) Kragl, U.; Gödde, A.; Wandrey, C.; Kinzy, W.; Cappon, J.J.; Lugtenburg, J.
Repetitive Batch as an Efficient Method for Preparative Scale Enzymic Synthesis of 5-Azido-Neuraminic Acid and 15N-L-Glutamic Acid
Tetrahedron: Asymmetry 4, 1193-1202 (1993)

(8) Kragl, U.; Vasic-Racki, D.; Wandrey, C.
Continuous Processes with Soluble Enzymes
Ind. J. Chem., Sect B. 32, 103-117 (1993)

(7) Kragl, U.; Bossow-Berke, B., Danzig, J.; Dreisbach, C., Wandrey, C.
Reaktionstechnik der enzymkatalysierten C-C-Verknüpfung
in T. Anken, U. Onken (Hrsg.)
Wege zu neuen Produkten und Verfahren der Biotechnologie
Dechema-Monographie Band 129, VCH Verlag Weinheim (1993)

(6) Kittelmann, M.; Klein, T.; Kragl, U.; Wandrey, C.; Ghisalba, O.
Preparative Enzymatic Synthesis of Activated Neuraminic Acid by Using a Microbial
Ann. N. Y. Acad. Sci. 672, 444-451 (1992)

(5) Kragl, U.; Appel, P.; Gygax, D.; Ghisalba, O.; Wandrey, C.
Aldolase for Use in Carbohydrate Synthesis: Enzymatic Reaction Engineering as a Tool for Process Optimization
In: S. Furusaki, I. Endo, R. Matsuno (Eds.): Biochemical Engineering for 2001, Proceedings
of Asia-Pacific Biochemical Engineering Conference 1992, Springer Verlag, Tokyo, 1992, S.

(4) Kragl, U.; Vascic-Racki, D.; Wandrey, C.
Kontinuierliche Reaktionsführung mit löslichen Enzymen
Chem.-Ing.-Tech. 64 (6), 499-509 (1992)

(3) Miethe, P., Jansen, I.; Niedermeyer, U.; Kragl, U.; Kula, M.-R.; Wandrey, C.; Mohr, K.-H.;
Meyer, H.-W.
Continuous Synthesis of (R)-(+)-Benzaldehydecyanohydrin using (R)-Oxynitrilase in   Lyotropic Liquid Crystal
Biocatalysis, 7, 61-73 (1992)

(2) Kragl, U.; Gygax, D.; Ghisalba, O.; Wandrey, C.
Enzymatische zweistufige Synthese von N-Acetylneuraminsäure im Enzym-Membran-Reaktor
Angew. Chem. 103 (7), 854-855 (1991)
Angew. Chem. Int. Ed. Engl. 30 (7), 827-828 (1991)

(1) Kragl, U.; Niedermeyer, U.; Kula, M.-R; Wandrey, C.
Engineering Aspects of  Enzyme Engineering - Continuous Asymmetric C-C Bond Formationin an Enzyme-Membrane-Reactor
Ann. N. Y. Acad. Sci. 613, 167-175 (1990)